Version 5.4
Homo sapiens Gene: MAD2L2
Summary
InnateDB Gene IDBG-89488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAD2L2
Gene Name MAD2 mitotic arrest deficient-like 2 (yeast)
Synonyms MAD2B; POLZ2; REV7
Species Homo sapiens
Ensembl Gene ENSG00000116670
Encoded Proteins
IDBP-89490
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-89492
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-89494
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-89496
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-89498
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-368846
MAD2 mitotic arrest deficient-like 2 (yeast)
IDBP-368853
MAD2 mitotic arrest deficient-like 2 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11674480-11691650
Strand Reverse strand
Band p36.22
Transcripts
ENST00000376692 ENSP00000365882
ENST00000235310 ENSP00000235310
ENST00000376672 ENSP00000365860
ENST00000376669 ENSP00000365857
ENST00000376667 ENSP00000365855
ENST00000376664
ENST00000376655
ENST00000445656 ENSP00000411807
ENST00000456915 ENSP00000400982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0005515 protein binding
GO:0008432 JUN kinase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001558 regulation of cell growth
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0007015 actin filament organization
GO:0007067 mitotic nuclear division
GO:0007094 mitotic spindle assembly checkpoint
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042177 negative regulation of protein catabolic process
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060564 negative regulation of mitotic anaphase-promoting complex activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0016035 zeta DNA polymerase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029003
View Gene Order
ENSBTAG00000013275
Not yet available
Pathways
NETPATH
REACTOME
REACT_822
Translesion synthesis by Pol zeta pathway
REACT_2198
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_2174
DNA Damage Bypass pathway
REACT_216
DNA Repair pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.19400
RefSeq NM_001127325 NM_006341
HUGO
OMIM
CCDS CCDS134
HPRD 07246
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca