InnateDB Protein
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IDBP-89498.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAD2L2
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Protein Name
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MAD2 mitotic arrest deficient-like 2 (yeast)
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Synonyms
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MAD2B; POLZ2; REV7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365855
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InnateDB Gene
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IDBG-89488 (MAD2L2)
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Protein Structure
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Function |
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269PubMed:11459825, ECO:0000269PubMed:11459826, ECO:0000269PubMed:17296730, ECO:0000269PubMed:17719540, ECO:0000269PubMed:19443654}.
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Subcellular Localization |
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:11717438}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001558
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regulation of cell growth
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GO:0006281
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DNA repair
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GO:0006302
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double-strand break repair
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GO:0006351
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transcription, DNA-templated
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GO:0007015
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actin filament organization
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GO:0007067
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mitotic nuclear division
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0010719
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negative regulation of epithelial to mesenchymal transition
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GO:0010944
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negative regulation of transcription by competitive promoter binding
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GO:0033138
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positive regulation of peptidyl-serine phosphorylation
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GO:0042177
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negative regulation of protein catabolic process
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GO:0042772
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DNA damage response, signal transduction resulting in transcription
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GO:0043433
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negative regulation of sequence-specific DNA binding transcription factor activity
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0060564
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negative regulation of mitotic anaphase-promoting complex activity
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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GO:2000048
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negative regulation of cell-cell adhesion mediated by cadherin
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GO:2000678
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negative regulation of transcription regulatory region DNA binding
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Cellular Component |
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PDB ID |
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InterPro |
IPR003511
DNA-binding HORMA
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PFAM |
PF02301
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UI95
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PhosphoSite |
PhosphoSite-Q9UI95
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TrEMBL |
B1AK45
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UniProt Splice Variant |
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Entrez Gene |
10459
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UniGene |
Hs.19400
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RefSeq |
NP_001120797
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HUGO |
HGNC:6764
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OMIM |
604094
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CCDS |
CCDS134
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HPRD |
07246
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IMGT |
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EMBL |
AF072933
AF080398
AF139365
AF157482
AK027327
AK094316
AL031731
BC015244
CH471130
DQ017900
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GenPept |
AAD30290
AAD41647
AAF20267
AAF34357
AAH15244
AAY26393
BAG51305
BAG52858
CAI20218
EAW71697
EAW71698
EAW71699
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