Version 5.4
Homo sapiens Protein: PDCD4
Summary
InnateDB Protein IDBP-89537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDCD4
Protein Name programmed cell death 4 (neoplastic transformation inhibitor)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000280154
InnateDB Gene IDBG-89535 (PDCD4)
Protein Structure
UniProt Annotation
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
Disease Associations
Tissue Specificity Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269PubMed:10632927, ECO:0000269PubMed:12898601, ECO:0000269PubMed:16449643}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007569 cell aging
GO:0043508 negative regulation of JUN kinase activity
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003891 Initiation factor eIF-4 gamma, MA3
IPR016024 Armadillo-type fold
PFAM PF02847
PRINTS
PIRSF
SMART SM00544
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53EL6
PhosphoSite PhosphoSite-Q53EL6
TrEMBL
UniProt Splice Variant
Entrez Gene 27250
UniGene Hs.733516
RefSeq NP_055271
HUGO HGNC:8763
OMIM 608610
CCDS CCDS7567
HPRD 10549
IMGT
EMBL AK223623 AK315295 AL136368 AL158163 BC015036 BC026104 BC031049 U83908 U96628
GenPept AAB42218 AAB67706 AAH15036 AAH26104 AAH31049 BAD97343 BAG37701 CAH72815 CAI40095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca