Version 5.4
Homo sapiens Protein: NFKBIE
Summary
InnateDB Protein IDBP-89545.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIE
Protein Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Synonyms IKBE;
Species Homo sapiens
Ensembl Protein ENSP00000275015
InnateDB Gene IDBG-89543 (NFKBIE)
Protein Structure
UniProt Annotation
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269PubMed:9315679}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 31 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042942 D-serine transport
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00221
PhosphoSite PhosphoSite-Q96F31
TrEMBL Q96F31
UniProt Splice Variant
Entrez Gene 4794
UniGene Hs.458276
RefSeq NP_004547
HUGO HGNC:7799
OMIM 604548
CCDS CCDS34463
HPRD 05181
IMGT
EMBL AF261937 AK301360 AL139392 BC011676 BC063609 CH471081 U91616
GenPept AAC51216 AAH11676 AAH63609 AAM27002 BAH13464 CAI20103 EAX04262 EAX04263

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca