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InnateDB Protein
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IDBP-89590.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGTRAP
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Protein Name
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angiotensin II receptor-associated protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365814
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InnateDB Gene
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IDBG-89584 (AGTRAP)
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Protein Structure
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| Function |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269PubMed:12960423}.
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| Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Golgi apparatus membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. {ECO:0000269PubMed:11733189}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
20
[view]
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| Protein-Protein |
20
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q6RW13
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| TrEMBL |
X6R9H3
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| UniProt Splice Variant |
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| Entrez Gene |
57085
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| UniGene |
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| RefSeq |
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| HUGO |
HGNC:13539
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| OMIM |
608729
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| CCDS |
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| HPRD |
16379
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| IMGT |
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| EMBL |
AL953897
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| GenPept |
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Version 5.4