Version 5.4
Homo sapiens Protein: AGTRAP
Summary
InnateDB Protein IDBP-89592.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGTRAP
Protein Name angiotensin II receptor-associated protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319713
InnateDB Gene IDBG-89584 (AGTRAP)
Protein Structure
UniProt Annotation
Function Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269PubMed:12960423}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Golgi apparatus membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:12960423}; Multi-pass membrane protein {ECO:0000269PubMed:12960423}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Disease Associations
Tissue Specificity Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. {ECO:0000269PubMed:11733189}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0008217 regulation of blood pressure
GO:0038166 angiotensin-activated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR009436 Angiotensin II, type I receptor-associated
PFAM PF06396
PRINTS
PIRSF
SMART SM00805
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6RW13
PhosphoSite PhosphoSite-Q6RW13
TrEMBL
UniProt Splice Variant
Entrez Gene 57085
UniGene
RefSeq NP_065083
HUGO HGNC:13539
OMIM 608729
CCDS CCDS136
HPRD 16379
IMGT
EMBL AF165187 AF312374 AL953897 AY488088 BC017328 BE782705 CA866314 CH471130
GenPept AAF89547 AAH17328 AAL26806 AAR25556 CAI15876 CAI15877 CAI15878 CAI15879 EAW71702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca