InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHOC2

Summary

InnateDB Protein

IDBP-89614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHOC2

Protein Name

soc-2 suppressor of clear homolog (C. elegans)

Synonyms

SIAA0862; SOC2; SUR8;

Species

Homo sapiens

Ensembl Protein

ENSP00000265277

InnateDB Gene

IDBG-89610 (SHOC2)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. {ECO:0000269PubMed:10783161, ECO:0000269PubMed:16630891}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19684605}. Nucleus {ECO:0000269PubMed:19684605}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.

Disease Associations

Noonan syndrome-like disorder with loose anagen hair (NSLH) [MIM:607721]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269PubMed:19684605}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019888	protein phosphatase regulator activity
GO:0019903	protein phosphatase binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0046579	positive regulation of Ras protein signal transduction
GO:0050790	regulation of catalytic activity