Version 5.4
Homo sapiens Gene: SHOC2
Summary
InnateDB Gene IDBG-89610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHOC2
Gene Name soc-2 suppressor of clear homolog (C. elegans)
Synonyms SIAA0862; SOC2; SUR8
Species Homo sapiens
Ensembl Gene ENSG00000108061
Encoded Proteins
IDBP-89612
soc-2 suppressor of clear homolog (C. elegans)
IDBP-89614
soc-2 suppressor of clear homolog (C. elegans)
IDBP-385427
soc-2 suppressor of clear homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:110919547-111013667
Strand Forward strand
Band q25.2
Transcripts
ENST00000369452 ENSP00000358464
ENST00000265277 ENSP00000265277
ENST00000451838 ENSP00000408275
ENST00000480155
ENST00000489390
ENST00000489783
ENST00000497305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019888 protein phosphatase regulator activity
GO:0019903 protein phosphatase binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0046579 positive regulation of Ras protein signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000164 protein phosphatase type 1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024976
View Gene Order
ENSBTAG00000007709
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.104315
RefSeq NM_001269039 NM_007373
HUGO
OMIM
CCDS CCDS58095 CCDS7568
HPRD 04144
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca