InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCN6

Summary

InnateDB Protein

IDBP-89758.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCN6

Protein Name

chloride channel 6

Synonyms

CLC-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000234488

InnateDB Gene

IDBG-89756 (CLCN6)

Protein Structure

UniProt Annotation

Function

Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:17534424}; Multi-pass membrane protein {ECO:0000269PubMed:17534424}. Note=Detected in detergent- resistant lipid rafts.

Disease Associations

Tissue Specificity

Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. {ECO:0000269PubMed:10198195, ECO:0000269PubMed:8543009, ECO:0000269PubMed:9224655}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity

Biological Process

GO:0006821	chloride transport
GO:0006884	cell volume homeostasis
GO:0007165	signal transduction
GO:0009612	response to mechanical stimulus
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport