Version 5.4
Homo sapiens Gene: CLCN6
Summary
InnateDB Gene IDBG-89756.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCN6
Gene Name chloride channel, voltage-sensitive 6
Synonyms CLC-6
Species Homo sapiens
Ensembl Gene ENSG00000011021
Encoded Proteins
IDBP-89758
chloride channel 6
IDBP-89760
chloride channel 6
IDBP-89762
chloride channel 6
IDBP-89764
chloride channel 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11806096-11843144
Strand Forward strand
Band p36.22
Transcripts
ENST00000346436 ENSP00000234488
ENST00000312413 ENSP00000308367
ENST00000376497 ENSP00000365680
ENST00000376496 ENSP00000365679
ENST00000376492
ENST00000376490
ENST00000376491
ENST00000494028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005524 ATP binding
GO:0015297 antiporter activity
Biological Process
GO:0006821 chloride transport
GO:0006884 cell volume homeostasis
GO:0007165 signal transduction
GO:0009612 response to mechanical stimulus
GO:0034220 ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029016
View Gene Order
ENSBTAG00000020700
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.193043
RefSeq NM_001256959 NM_001286
HUGO
OMIM
CCDS CCDS138 CCDS57972
HPRD 04102
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca