InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPPA

Summary

InnateDB Protein

IDBP-89855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPA

Protein Name

natriuretic peptide A

Synonyms

ANF; ANP; ATFB6; ATRST2; CDD-ANF; PND;

Species

Homo sapiens

Ensembl Protein

ENSP00000365663

InnateDB Gene

IDBG-89853 (NPPA)

Protein Structure

UniProt Annotation

Function

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269PubMed:1672777}.

Subcellular Localization

Secreted.

Disease Associations

Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269PubMed:18614783}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001666	response to hypoxia
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006182	cGMP biosynthetic process
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0010467	gene expression
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030308	negative regulation of cell growth
GO:0032868	response to insulin
GO:0050880	regulation of blood vessel size
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042629	mast cell granule
GO:0048471	perinuclear region of cytoplasm