InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPPA

Summary

InnateDB Gene

IDBG-89853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPA

Gene Name

natriuretic peptide A

Synonyms

ANF; ANP; ATFB6; ATRST2; CDD-ANF; PND

Species

Homo sapiens

Ensembl Gene

ENSG00000175206

Encoded Proteins

IDBP-89855

natriuretic peptide A

IDBP-89857

natriuretic peptide A

IDBP-807343

natriuretic peptide A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:11845709-11848345

Strand

Reverse strand

Band

p36.22

Transcripts

ENST00000376480	ENSP00000365663
ENST00000376476	ENSP00000365659
ENST00000610706	ENSP00000483195

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001666	response to hypoxia
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006182	cGMP biosynthetic process
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0010467	gene expression
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030308	negative regulation of cell growth
GO:0032868	response to insulin
GO:0050880	regulation of blood vessel size
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042629	mast cell granule
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041616

View Gene Order

ENSBTAG00000006709

Not yet available

Pathways

NETPATH

REACTOME

REACT_75925

Amyloids pathway

REACT_118713

YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

ap1_pathway

AP-1 transcription factor network

Cross-References

SwissProt

TrEMBL

B0ZBE8

UniProt Splice Variant

Entrez Gene

4878

UniGene

RefSeq

NM_006172

HUGO

HGNC:7939

OMIM

108780

CCDS

CCDS139

HPRD

00164

IMGT

EMBL

AL021155 EU326308

GenPept

ACA05915

RNA Seq Atlas

4878