InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP39A1

Summary

InnateDB Protein

IDBP-89893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP39A1

Protein Name

cytochrome P450, family 39, subfamily A, polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000275016

InnateDB Gene

IDBG-89891 (CYP39A1)

Protein Structure

UniProt Annotation

Function

Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Liver specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008387	steroid 7-alpha-hydroxylase activity
GO:0008396	oxysterol 7-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033782	24-hydroxycholesterol 7alpha-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0007586	digestion
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0030573	bile acid catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process