InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP39A1

Summary

InnateDB Gene

IDBG-89891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP39A1

Gene Name

cytochrome P450, family 39, subfamily A, polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000146233

Encoded Proteins

IDBP-89893

cytochrome P450, family 39, subfamily A, polypeptide 1

IDBP-808099

cytochrome P450, family 39, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:46549580-46652830

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000275016	ENSP00000275016
ENST00000489657
ENST00000476076
ENST00000480804
ENST00000619708	ENSP00000477769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008387	steroid 7-alpha-hydroxylase activity
GO:0008396	oxysterol 7-alpha-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033782	24-hydroxycholesterol 7alpha-hydroxylase activity

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0007586	digestion
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0030573	bile acid catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process