InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXNB3

Summary

InnateDB Protein

IDBP-89920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXNB3

Protein Name

plexin B3

Synonyms

PLEXB3; PLEXR; PLXN6;

Species

Homo sapiens

Ensembl Protein

ENSP00000355378

InnateDB Gene

IDBG-89918 (PLXNB3)

Protein Structure

UniProt Annotation

Function

Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269PubMed:15218527, ECO:0000269PubMed:20696765, ECO:0000269PubMed:21706053}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15218527, ECO:0000269PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269PubMed:15218527, ECO:0000269PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane.

Disease Associations

Tissue Specificity

Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. {ECO:0000269PubMed:16122393, ECO:0000269PubMed:20696765, ECO:0000269PubMed:21706053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0010593	negative regulation of lamellipodium assembly
GO:0030336	negative regulation of cell migration
GO:0034260	negative regulation of GTPase activity
GO:0050918	positive chemotaxis
GO:0060326	cell chemotaxis
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ULL4