Version 5.4
Homo sapiens Gene: PLXNB3
Summary
InnateDB Gene IDBG-89918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNB3
Gene Name plexin B3
Synonyms PLEXB3; PLEXR; PLXN6
Species Homo sapiens
Ensembl Gene ENSG00000198753
Encoded Proteins
IDBP-89920
plexin B3
IDBP-383003
plexin B3
IDBP-383005
plexin B3
IDBP-383011
plexin B3
IDBP-591060
plexin B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153764196-153779346
Strand Forward strand
Band q28
Transcripts
ENST00000361971 ENSP00000355378
ENST00000411613 ENSP00000391650
ENST00000455214 ENSP00000396048
ENST00000448847 ENSP00000412454
ENST00000482654
ENST00000485980
ENST00000469190
ENST00000472415
ENST00000538966 ENSP00000442736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
GO:0019904 protein domain specific binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0010593 negative regulation of lamellipodium assembly
GO:0030336 negative regulation of cell migration
GO:0034260 negative regulation of GTPase activity
GO:0050918 positive chemotaxis
GO:0060326 cell chemotaxis
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031385
View Gene Order
ENSBTAG00000010146
Not yet available
Pathways
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q9ULL4
TrEMBL
UniProt Splice Variant
Entrez Gene 5365
UniGene Hs.632833
RefSeq NM_005393 NM_001163257
HUGO HGNC:9105
OMIM 300214
CCDS CCDS14729 CCDS55536
HPRD 02198
IMGT
EMBL AB033032 AF149019 AK295762 U52111
GenPept AAG01376 BAA86520 BAH12182
RNA Seq Atlas 5365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca