Version 5.4
Homo sapiens Protein: UCK1
Summary
InnateDB Protein IDBP-90049.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCK1
Protein Name uridine-cytidine kinase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361289
InnateDB Gene IDBG-90047 (UCK1)
Protein Structure
UniProt Annotation
Function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004140 dephospho-CoA kinase activity
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019206 nucleoside kinase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0008152 metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
GO:0043097 pyrimidine nucleoside salvage
GO:0044206 UMP salvage
GO:0044211 CTP salvage
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000764 Uridine kinase like
IPR001977 Dephospho-CoA kinase
IPR006083 Phosphoribulokinase/uridine kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01121
PF00485
PRINTS PR00988
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HA47
PhosphoSite PhosphoSite-Q9HA47
TrEMBL
UniProt Splice Variant
Entrez Gene 83549
UniGene Hs.9597
RefSeq NP_113620
HUGO HGNC:14859
OMIM 609328
CCDS CCDS6944
HPRD 18256
IMGT
EMBL AF125106 AF237290 AF254133 AK022317 AK295471 AL358781 BC015547 BC091495 CH471090 CR457281
GenPept AAH15547 AAH91495 AAK28324 AAK49122 AAL75943 BAB14010 BAG58400 CAG33562 CAI40228 CAI40229 CAI40231 EAW87983

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca