InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP7

Summary

InnateDB Protein

IDBP-90076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP7

Protein Name

caspase 7, apoptosis-related cysteine peptidase

Synonyms

CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000358324

InnateDB Gene

IDBG-90066 (CASP7)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp--Gly- 217' bond. Overexpression promotes programmed cell death.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	94 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0045087	innate immune response (InnateDB)
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt