InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF1

Summary

InnateDB Protein

IDBP-90123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF1

Protein Name

Rap guanine nucleotide exchange factor (GEF) 1

Synonyms

C3G; GRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000361263

InnateDB Gene

IDBG-90109 (RAPGEF1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269PubMed:17724123, ECO:0000269PubMed:21840392, ECO:0000269PubMed:7806500}.

Subcellular Localization

Early endosome {ECO:0000269PubMed:17724123}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001568	blood vessel development
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051898	negative regulation of protein kinase B signaling
GO:0061028	establishment of endothelial barrier
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13905