InnateDB Protein
|
IDBP-90189.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MED27
|
Protein Name
|
mediator complex subunit 27
|
Synonyms
|
CRAP34; CRSP34; CRSP8; TRAP37;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000292035
|
InnateDB Gene
|
IDBG-90181 (MED27)
|
Protein Structure
|
|
Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269PubMed:10882111, ECO:0000269PubMed:9989412}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:10882111, ECO:0000269PubMed:9989412}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
48
[view]
|
Protein-Protein |
48
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003713
|
transcription coactivator activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR021627
Mediator complex, subunit Med27
|
PFAM |
PF11571
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6P2C8
|
PhosphoSite |
PhosphoSite-Q6P2C8
|
TrEMBL |
U4Q365
|
UniProt Splice Variant |
|
Entrez Gene |
9442
|
UniGene |
|
RefSeq |
NP_004260
|
HUGO |
HGNC:2377
|
OMIM |
605044
|
CCDS |
CCDS6945
|
HPRD |
05438
|
IMGT |
|
EMBL |
AF104252
AF230382
AL160271
AL513102
AL603649
AL713892
BC002878
BC064608
CH471090
DQ099387
HG518166
|
GenPept |
AAD12721
AAF37290
AAH02878
AAH64608
AAZ13763
CAH72529
CAH72530
CAH72546
CAH72547
CAI13386
CAI13387
CAI17283
CAI17284
CDI06889
EAW87990
EAW87993
|
|
|