InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AFAP1L2

Summary

InnateDB Protein

IDBP-90376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AFAP1L2

Protein Name

actin filament associated protein 1-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303042

InnateDB Gene

IDBG-90372 (AFAP1L2)

Protein Structure

UniProt Annotation

Function

May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269PubMed:17412687}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17412687}.

Disease Associations

Tissue Specificity

Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. {ECO:0000269PubMed:17412687}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017124	SH3 domain binding
GO:0030296	protein tyrosine kinase activator activity
GO:0042169	SH2 domain binding

Biological Process

GO:0006954	inflammatory response
GO:0007346	regulation of mitotic cell cycle
GO:0032675	regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0061098	positive regulation of protein tyrosine kinase activity