Version 5.4
Homo sapiens Gene: AFAP1L2
Summary
InnateDB Gene IDBG-90372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFAP1L2
Gene Name actin filament associated protein 1-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169129
Encoded Proteins
IDBP-90374
actin filament associated protein 1-like 2
IDBP-90376
actin filament associated protein 1-like 2
IDBP-385758
actin filament associated protein 1-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:114294824-114404756
Strand Reverse strand
Band q25.3
Transcripts
ENST00000369271 ENSP00000358276
ENST00000304129 ENSP00000303042
ENST00000419268 ENSP00000396781
ENST00000491814
ENST00000486300
ENST00000483496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017124 SH3 domain binding
GO:0030296 protein tyrosine kinase activator activity
GO:0042169 SH2 domain binding
Biological Process
GO:0006954 inflammatory response
GO:0007346 regulation of mitotic cell cycle
GO:0032675 regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0061098 positive regulation of protein tyrosine kinase activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025083
View Gene Order
ENSBTAG00000004895
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501106
RefSeq NM_001001936 NM_001287824 NM_032550 XM_005270239 XM_005270240
HUGO
OMIM
CCDS CCDS31286 CCDS31287
HPRD 13902
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca