InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM3

Summary

InnateDB Protein

IDBP-90551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM3

Protein Name

minichromosome maintenance complex component 3

Synonyms

HCC5; P1-MCM3; P1.h; RLFB;

Species

Homo sapiens

Ensembl Protein

ENSP00000229854

InnateDB Gene

IDBG-90549 (MCM3)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	130 [view]
Protein-Protein	122 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005658	alpha DNA polymerase:primase complex
GO:0005813	centrosome
GO:0016020	membrane
GO:0042555	MCM complex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR003593 AAA+ ATPase domain
IPR008046 DNA replication licensing factor Mcm3
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493

PRINTS

PR01657
PR01659

PIRSF

SMART

SM00350
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt