InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDM2

Summary

InnateDB Protein

IDBP-90605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM2

Protein Name

PR domain containing 2, with ZNF domain

Synonyms

HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000235372

InnateDB Gene

IDBG-90601 (PRDM2)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269PubMed:14633678}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14633678, ECO:0000269PubMed:7538672, ECO:0000269PubMed:9006946}.

Disease Associations

Tissue Specificity

Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. {ECO:0000269PubMed:8654390, ECO:0000269PubMed:9006946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046872	metal ion binding