Version 5.4
Homo sapiens Gene: PRDM2
Summary
InnateDB Gene IDBG-90601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDM2
Gene Name PR domain containing 2, with ZNF domain
Synonyms HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
Species Homo sapiens
Ensembl Gene ENSG00000116731
Encoded Proteins
IDBP-90603
PR domain containing 2, with ZNF domain
IDBP-90605
PR domain containing 2, with ZNF domain
IDBP-90607
PR domain containing 2, with ZNF domain
IDBP-90609
PR domain containing 2, with ZNF domain
IDBP-292423
PR domain containing 2, with ZNF domain
IDBP-370483
PR domain containing 2, with ZNF domain
IDBP-474543
PR domain containing 2, with ZNF domain
IDBP-482657
PR domain containing 2, with ZNF domain
IDBP-479092
PR domain containing 2, with ZNF domain
IDBP-481206
PR domain containing 2, with ZNF domain
IDBP-809274
PR domain containing 2, with ZNF domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:13700198-13825079
Strand Forward strand
Band p36.21
Transcripts
ENST00000376048 ENSP00000365216
ENST00000235372 ENSP00000235372
ENST00000311066 ENSP00000312352
ENST00000343137 ENSP00000341621
ENST00000407521 ENSP00000384430
ENST00000413440 ENSP00000411103
ENST00000484063 ENSP00000423010
ENST00000491134 ENSP00000424253
ENST00000502727
ENST00000502724
ENST00000491815
ENST00000503842 ENSP00000425028
ENST00000505823 ENSP00000426737
ENST00000487453 ENSP00000474273
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034968 histone lysine methylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057637
View Gene Order
ENSBTAG00000020552
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371823 Hs.613210
RefSeq NM_001007257 NM_001135610 NM_012231 NM_015866 XM_005245992 XM_005245993 XM_005245994 XM_005245995 XM_005245996 XM_005245997 XM_005245998 XM_006710877 XM_006710878 XM_006710879 XM_006710880
HUGO
OMIM
CCDS CCDS150 CCDS151 CCDS30603 CCDS44061
HPRD 03120
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca