InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HCFC1

Summary

InnateDB Protein

IDBP-90673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCFC1

Protein Name

host cell factor C1 (VP16-accessory protein)

Synonyms

CFF; HCF-1; HCF1; HFC1; MRX3; PPP1R89; VCAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000309555

InnateDB Gene

IDBG-90667 (HCFC1)

Protein Structure

UniProt Annotation

Function

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269PubMed:10629049, ECO:0000269PubMed:10675337, ECO:0000269PubMed:10779346, ECO:0000269PubMed:10920196, ECO:0000269PubMed:12244100, ECO:0000269PubMed:12670868, ECO:0000269PubMed:14532282, ECO:0000269PubMed:15190068, ECO:0000269PubMed:16624878, ECO:0000269PubMed:17578910, ECO:0000269PubMed:20018852, ECO:0000269PubMed:20200153, ECO:0000269PubMed:9990006}.

Subcellular Localization

Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER.

Disease Associations

Mental retardation, X-linked 3 (MRX3) [MIM:309541]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269PubMed:23000143}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269PubMed:9389645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 133 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	133 [view]
Protein-Protein	129 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0010628	positive regulation of gene expression
GO:0019046	release from viral latency
GO:0043254	regulation of protein complex assembly
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0043025	neuronal cell body
GO:0048188	Set1C/COMPASS complex
GO:0070461	SAGA-type complex
GO:0070688	MLL5-L complex
GO:0071339	MLL1 complex