InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100P

Summary

InnateDB Protein

IDBP-9074.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100P

Protein Name

S100 calcium binding protein P

Synonyms

MIG9;

Species

Homo sapiens

Ensembl Protein

ENSP00000296370

InnateDB Gene

IDBG-9072 (S100P)

Protein Structure

UniProt Annotation

Function

May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269PubMed:14617629, ECO:0000269PubMed:19111582, ECO:0000269PubMed:22399290}.

Subcellular Localization

Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium- dependent manner.

Disease Associations

Tissue Specificity

Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up- regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. {ECO:0000269PubMed:14672411, ECO:0000269PubMed:15632002}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding
GO:0050786	RAGE receptor binding