InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP9

Summary

InnateDB Protein

IDBP-90899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP9

Protein Name

caspase 9, apoptosis-related cysteine peptidase

Synonyms

APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56;

Species

Homo sapiens

Ensembl Protein

ENSP00000330237

InnateDB Gene

IDBG-90895 (CASP9)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. {ECO:0000269PubMed:16857965}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007568	aging
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411	response to UV
GO:0014070	response to organic cyclic compound
GO:0030220	platelet formation
GO:0032025	response to cobalt ion
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0034349	glial cell apoptotic process
GO:0034644	cellular response to UV
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042770	signal transduction in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0046677	response to antibiotic
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:2001020	regulation of response to DNA damage stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0043293	apoptosome

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References