Version 5.4
Homo sapiens Gene: CASP9
Summary
InnateDB Gene IDBG-90895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP9
Gene Name caspase 9, apoptosis-related cysteine peptidase
Synonyms APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56
Species Homo sapiens
Ensembl Gene ENSG00000132906
Encoded Proteins
IDBP-90897
caspase 9, apoptosis-related cysteine peptidase
IDBP-90899
caspase 9, apoptosis-related cysteine peptidase
IDBP-90901
caspase 9, apoptosis-related cysteine peptidase
IDBP-227433
caspase 9, apoptosis-related cysteine peptidase
IDBP-371034
caspase 9, apoptosis-related cysteine peptidase
IDBP-371037
caspase 9, apoptosis-related cysteine peptidase
IDBP-371039
caspase 9, apoptosis-related cysteine peptidase
IDBP-599556
caspase 9, apoptosis-related cysteine peptidase
IDBP-811254
caspase 9, apoptosis-related cysteine peptidase
IDBP-586503
caspase 9, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:15490832-15526534
Strand Reverse strand
Band p36.21
Transcripts
ENST00000375890 ENSP00000365051
ENST00000333868 ENSP00000330237
ENST00000348549 ENSP00000255256
ENST00000400777 ENSP00000383588
ENST00000424908 ENSP00000408691
ENST00000447522 ENSP00000396540
ENST00000440484 ENSP00000411304
ENST00000474305 ENSP00000449216
ENST00000469637 ENSP00000480785
ENST00000546424 ENSP00000449584
ENST00000546969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 72 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007568 aging
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 response to UV
GO:0014070 response to organic cyclic compound
GO:0030220 platelet formation
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0034349 glial cell apoptotic process
GO:0034644 cellular response to UV
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042770 signal transduction in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0046677 response to antibiotic
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0071407 cellular response to organic cyclic compound
GO:0071549 cellular response to dexamethasone stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:2001020 regulation of response to DNA damage stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043293 apoptosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028914
View Gene Order
ENSBTAG00000002472
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
REACTOME
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_1767
SMAC-mediated dissociation of IAP:caspase complexes pathway
REACT_2190
SMAC binds to IAPs pathway
REACT_607
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_89
Formation of apoptosome pathway
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_666
SMAC-mediated apoptotic response pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_963
Apoptotic factor-mediated response pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_831
Cytochrome c-mediated apoptotic response pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_13648
Regulation of Apoptosis pathway
REACT_116125
Disease pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04210
Apoptosis pathway
hsa05213
Endometrial cancer pathway
hsa05010
Alzheimer's disease pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05212
Pancreatic cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
p75ntrpathway
p75(NTR)-mediated signaling
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.329502
RefSeq NM_001229 NM_001278054 NM_032996 XM_005246014
HUGO
OMIM
CCDS CCDS158 CCDS159 CCDS59995
HPRD 03756
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca