InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICK

Summary

InnateDB Protein

IDBP-90917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICK

Protein Name

intestinal cell (MAK-like) kinase

Synonyms

ECO; LCK2; MRK;

Species

Homo sapiens

Ensembl Protein

ENSP00000263043

InnateDB Gene

IDBG-90915 (ICK)

Protein Structure

UniProt Annotation

Function

May play a key role in the development of multiple organ systems and particularly in cardiac development. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12103360}. Cytoplasm, cytosol {ECO:0000250}. Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168). {ECO:0000269PubMed:12103360}.

Disease Associations

Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. {ECO:0000269PubMed:19185282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. {ECO:0000269PubMed:10699974, ECO:0000269PubMed:12103360}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0035556	intracellular signal transduction
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt