Version 5.4
Homo sapiens Gene: ICK
Summary
InnateDB Gene IDBG-90915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICK
Gene Name intestinal cell (MAK-like) kinase
Synonyms ECO; LCK2; MRK
Species Homo sapiens
Ensembl Gene ENSG00000112144
Encoded Proteins
IDBP-90917
intestinal cell (MAK-like) kinase
IDBP-90921
intestinal cell (MAK-like) kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:53001279-53061802
Strand Reverse strand
Band p12.1
Transcripts
ENST00000350082 ENSP00000263043
ENST00000356971 ENSP00000349458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0035556 intracellular signal transduction
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009828
View Gene Order
ENSBTAG00000015590
Not yet available
Cross-References
SwissProt Q9UPZ9
TrEMBL A0A024RD59
UniProt Splice Variant
Entrez Gene 22858
UniGene Hs.417022 Hs.606009
RefSeq NM_014920 NM_016513
HUGO HGNC:21219
OMIM 612325
CCDS CCDS4949
HPRD
IMGT
EMBL AB023153 AF152469 AF225919 AL031178 AL162581 BC035807 BC136420 BC136421 BC152464 CH471081
GenPept AAF37278 AAG43364 AAH35807 AAI36421 AAI36422 AAI52465 BAA76780 CAI19518 CAI20261 EAX04400 EAX04402 EAX04403 EAX04404
RNA Seq Atlas 22858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca