InnateDB Protein
|
IDBP-90948.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CACUL1
|
Protein Name
|
chromosome 10 open reading frame 46
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000358147
|
InnateDB Gene
|
IDBG-90944 (CACUL1)
|
Protein Structure
|
|
Function |
Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. {ECO:0000269PubMed:19829063}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase. {ECO:0000269PubMed:19829063}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0000082
|
G1/S transition of mitotic cell cycle
|
GO:0006511
|
ubiquitin-dependent protein catabolic process
|
GO:0008284
|
positive regulation of cell proliferation
|
GO:0045860
|
positive regulation of protein kinase activity
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001373
Cullin, N-terminal
IPR016159
Cullin repeat-like-containing domain
|
PFAM |
PF00888
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q86Y37
|
PhosphoSite |
PhosphoSite-Q86Y37
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
143384
|
UniGene |
Hs.743319
|
RefSeq |
NP_722517
|
HUGO |
HGNC:23727
|
OMIM |
|
CCDS |
CCDS41570
|
HPRD |
12576
|
IMGT |
|
EMBL |
AJ544771
AK097728
AL139407
AY743663
BC038294
|
GenPept |
AAH38294
AAU89709
BAC05153
CAD67614
CAH73727
|
|
|