InnateDB Protein
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IDBP-90995.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF3A
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Protein Name
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eukaryotic translation initiation factor 3, subunit A
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Synonyms
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EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167; p180; p185; TIF32;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358140
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InnateDB Gene
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IDBG-90993 (EIF3A)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255HAMAP- Rule:MF_03000, ECO:0000269PubMed:11169732}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03000, ECO:0000269PubMed:9150439}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
139
[view]
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Protein-Protein |
138
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000717
Proteasome component (PCI) domain
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q14152
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PhosphoSite |
PhosphoSite-Q14152
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TrEMBL |
F5H335
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UniProt Splice Variant |
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Entrez Gene |
8661
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UniGene |
Hs.713331
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RefSeq |
NP_003741
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HUGO |
HGNC:3271
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OMIM |
602039
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CCDS |
CCDS7608
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HPRD |
03618
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IMGT |
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EMBL |
AL355598
CH471066
D50929
U58046
U58047
U78311
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GenPept |
AAB41584
AAB41586
AAB80695
BAA09488
CAI14127
EAW49408
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