Version 5.4
Homo sapiens Protein: TINAG
Summary
InnateDB Protein IDBP-91115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TINAG
Protein Name tubulointerstitial nephritis antigen
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259782
InnateDB Gene IDBG-91109 (TINAG)
Protein Structure
UniProt Annotation
Function Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. {ECO:0000269PubMed:8770961}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:10752525, ECO:0000269PubMed:1762287}.
Disease Associations
Tissue Specificity Expressed in the kidney cortex, small intestine and cornea. {ECO:0000269PubMed:10652240, ECO:0000269PubMed:10752525, ECO:0000269PubMed:1762287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0008234 cysteine-type peptidase activity
GO:0030247 polysaccharide binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0006955 immune response
GO:0007155 cell adhesion
Cellular Component
GO:0005604 basement membrane
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR001212 Somatomedin B domain
PFAM PF00112
PF01033
PRINTS PR00705
PIRSF
SMART SM00645
SM00201
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJW2
PhosphoSite PhosphoSite-Q9UJW2
TrEMBL B1AQ11
UniProt Splice Variant
Entrez Gene 27283
UniGene
RefSeq NP_055279
HUGO HGNC:14599
OMIM 606749
CCDS CCDS4955
HPRD 09483
IMGT
EMBL AB022277 AF195116 AF195117 AK312918 AL359380 AL589946 CH471081
GenPept AAF08931 AAF08932 BAA84949 BAG35763 CAH70302 CAI16272 EAX04437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca