Version 5.4
Homo sapiens Protein: FBLIM1
Summary
InnateDB Protein IDBP-91128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBLIM1
Protein Name filamin binding LIM protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364921
InnateDB Gene IDBG-91122 (FBLIM1)
Protein Structure
UniProt Annotation
Function Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269PubMed:12496242, ECO:0000269PubMed:12679033, ECO:0000269PubMed:18829455, ECO:0000269PubMed:19074766}.
Subcellular Localization Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
Disease Associations
Tissue Specificity Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269PubMed:12496242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0031005 filamin binding
Biological Process
GO:0008360 regulation of cell shape
GO:0016337 single organismal cell-cell adhesion
GO:0033623 regulation of integrin activation
GO:0034329 cell junction assembly
Cellular Component
GO:0001725 stress fiber
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0005938 cell cortex
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WUP2
PhosphoSite PhosphoSite-Q8WUP2
TrEMBL E7EPI5
UniProt Splice Variant
Entrez Gene 54751
UniGene Hs.739205
RefSeq NP_060026
HUGO HGNC:24686
OMIM 607747
CCDS CCDS163
HPRD 09669
IMGT
EMBL AF459643 AK027444 AK055259 AL133035 AL450998 AY180161 BC019895
GenPept AAH19895 AAO15549 AAO49012 BAB55115 BAG51492 CAB61365 CAH70853 CAH70854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca