InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAG3

Summary

InnateDB Protein

IDBP-91220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG3

Protein Name

BCL2-associated athanogene 3

Synonyms

BAG-3; BIS; CAIR-1; MFM6;

Species

Homo sapiens

Ensembl Protein

ENSP00000358081

InnateDB Gene

IDBG-91218 (BAG3)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

Subcellular Localization

Disease Associations

Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. {ECO:0000269PubMed:19085932, ECO:0000269PubMed:21361913}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:21353195, ECO:0000269PubMed:21459883, ECO:0000269PubMed:21898660}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 437 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	437 [view]
Protein-Protein	437 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0007420	brain development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0021510	spinal cord development
GO:0043066	negative regulation of apoptotic process
GO:0050821	protein stabilization
GO:0071260	cellular response to mechanical stimulus
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand