Version 5.4
Homo sapiens Protein: COL21A1
Summary
InnateDB Protein IDBP-91227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL21A1
Protein Name collagen, type XXI, alpha 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000244728
InnateDB Gene IDBG-91221 (COL21A1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:11863369}. Cytoplasm {ECO:0000269PubMed:11863369}. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.
Disease Associations
Tissue Specificity Highly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes. Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium. {ECO:0000269PubMed:11566190, ECO:0000269PubMed:11863369}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005788 endoplasmic reticulum lumen
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR001791 Laminin G domain
IPR002035 von Willebrand factor, type A
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00054
PF02210
PF00092
PF01391
PRINTS
PIRSF
SMART SM00210
SM00282
SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P44
PhosphoSite PhosphoSite-Q96P44
TrEMBL A6PVD9
UniProt Splice Variant
Entrez Gene 81578
UniGene Hs.645200
RefSeq NP_110447
HUGO HGNC:17025
OMIM 610002
CCDS CCDS55025
HPRD 09884
IMGT
EMBL AF330693 AF370383 AF414088 AF438327 AK313398 AL031779 AL031782 AL034452 AL136624 AL450430 AL513530 AL590675 BC045597 BC126108
GenPept AAH45597 AAI26109 AAL02227 AAL50033 AAL86699 AAQ15219 BAG36196 CAB66559 CAH73912 CAH73913 CAI22395 CAI22396 CAI22496 CAI22497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca