Version 5.4
Homo sapiens Protein: ARHGEF19
Summary
InnateDB Protein IDBP-91421.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF19
Protein Name Rho guanine nucleotide exchange factor (GEF) 19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000270747
InnateDB Gene IDBG-91417 (ARHGEF19)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035023 regulation of Rho protein signal transduction
GO:0042060 wound healing
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF00169
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IW93
PhosphoSite PhosphoSite-Q8IW93
TrEMBL
UniProt Splice Variant
Entrez Gene 128272
UniGene Hs.591532
RefSeq NP_694945
HUGO HGNC:26604
OMIM 612496
CCDS CCDS170
HPRD 10659
IMGT
EMBL AK091281 AL109627 BC012982 BC040640
GenPept AAH12982 AAH40640 BAC03627 CAI22566 CAI22567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca