Version 5.4
Homo sapiens Protein: TACC2
Summary
InnateDB Protein IDBP-91724.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACC2
Protein Name transforming, acidic coiled-coil containing protein 2
Synonyms AZU-1; ECTACC;
Species Homo sapiens
Ensembl Protein ENSP00000353763
InnateDB Gene IDBG-91710 (TACC2)
Protein Structure
UniProt Annotation
Function Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269PubMed:10749935}.
Subcellular Localization Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Disease Associations
Tissue Specificity Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. {ECO:0000269PubMed:11161455, ECO:0000269PubMed:12620397}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0035257 nuclear hormone receptor binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID
InterPro IPR007707 Transforming acidic coiled-coil
PFAM PF05010
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95359
PhosphoSite PhosphoSite-O95359
TrEMBL
UniProt Splice Variant
Entrez Gene 10579
UniGene Hs.501252
RefSeq NP_996742
HUGO HGNC:11523
OMIM 605302
CCDS CCDS7628
HPRD 05600
IMGT
EMBL AC063960 AF095791 AF176646 AF220152 AF528098 AF528099 AL135793 AL713712 BC000999 BC039311
GenPept AAC64968 AAF29537 AAF63433 AAH00999 AAH39311 AAO62629 AAO62630 CAD28509 CAI95127 CAI95128 CAI95131 CAI95134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca