InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR5

Summary

InnateDB Protein

IDBP-91738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR5

Protein Name

WD repeat domain 5

Synonyms

BIG-3; CFAP89; SWD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000351446

InnateDB Gene

IDBG-91736 (WDR5)

Protein Structure

UniProt Annotation

Function

Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. {ECO:0000269PubMed:16600877, ECO:0000269PubMed:16829960, ECO:0000269PubMed:19103755, ECO:0000269PubMed:19556245, ECO:0000269PubMed:20018852}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17355966, ECO:0000269PubMed:20018852}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	194 [view]
Protein-Protein	192 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0001501	skeletal system development
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045722	positive regulation of gluconeogenesis
GO:0048511	rhythmic process
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0035097	histone methyltransferase complex
GO:0048188	Set1C/COMPASS complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08662

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt