Homo sapiens Protein: BAI3
Summary
InnateDB Protein IDBP-91806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAI3
Protein Name brain-specific angiogenesis inhibitor 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359630
InnateDB Gene IDBG-91804 (BAI3)
Protein Structure
UniProt Annotation
Function May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21262840, ECO:0000269PubMed:22333914}; Multi-pass membrane protein {ECO:0000269PubMed:21262840, ECO:0000269PubMed:22333914}.
Disease Associations
Tissue Specificity Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0016525 negative regulation of angiogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR000859 CUB domain
IPR000884 Thrombospondin, type 1 repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497
PFAM PF01825
PF00002
PF00431
PF00090
PF02793
PF12003
PRINTS PR00249
PR01694
PIRSF
SMART SM00303
SM00042
SM00209
SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60242
PhosphoSite PhosphoSite-O60242
TrEMBL S4R3D0
UniProt Splice Variant
Entrez Gene 577
UniGene Hs.13261
RefSeq NP_001695
HUGO HGNC:945
OMIM 602684
CCDS CCDS4968
HPRD 04064
IMGT
EMBL AB005299 AB011122 AK293560 AL035469 AL078598 AL133378 AL158051 AL160401 AL356117 AL359714 AL391807 AL589875 BC111720 CH471051
GenPept AAI11721 BAA25363 BAA25476 BAH11536 CAC34969 CAH71522 CAH71772 CAH73864 CAI19625 CAI21673 EAW48837