Version 5.4
Homo sapiens Protein: SMAP1
Summary
InnateDB Protein IDBP-92088.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMAP1
Protein Name small ArfGAP 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000313382
InnateDB Gene IDBG-92082 (SMAP1)
Protein Structure
UniProt Annotation
Function GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach. {ECO:0000269PubMed:12119110}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYB5
PhosphoSite PhosphoSite-Q8IYB5
TrEMBL
UniProt Splice Variant
Entrez Gene 60682
UniGene Hs.485717
RefSeq NP_068759
HUGO HGNC:19651
OMIM 611372
CCDS CCDS4973
HPRD 18072
IMGT
EMBL AF442495 AK023221 AK222711 AL121961 AL354943 AL591049 AL833906 AY055003 AY055004 AY055005 AY055006 AY055007 AY055008 AY055009 AY055010 AY055011 AY055012 AY055013 AY055014 AY055015 BC008672 BC028074 BC036123
GenPept AAH08672 AAH28074 AAH36123 AAL14714 AAL14715 AAL14716 AAL14717 AAP97320 BAB14473 BAD96431 CAD38762 CAI12310 CAI12311 CAI12312 CAI14240 CAI14241 CAI14242 CAI42146 CAI42147 CAI42148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca