InnateDB Protein
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IDBP-92124.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBR4
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Protein Name
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ubiquitin protein ligase E3 component n-recognin 4
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Synonyms
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p600; RBAF600; ZUBR1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364372
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InnateDB Gene
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IDBG-92114 (UBR4)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269PubMed:16214886, ECO:0000269PubMed:23932781}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
53
[view]
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Protein-Protein |
53
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q5T4S7
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TrEMBL |
X6R960
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UniProt Splice Variant |
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Entrez Gene |
23352
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UniGene |
Hs.678940
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RefSeq |
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HUGO |
HGNC:30313
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OMIM |
609890
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CCDS |
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HPRD |
10184
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IMGT |
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EMBL |
AL137127
AL357564
BC007962
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GenPept |
AAH07962
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