Version 5.4
Homo sapiens Gene: UBR4
Summary
InnateDB Gene IDBG-92114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBR4
Gene Name ubiquitin protein ligase E3 component n-recognin 4
Synonyms p600; RBAF600; ZUBR1
Species Homo sapiens
Ensembl Gene ENSG00000127481
Encoded Proteins
IDBP-92118
ubiquitin protein ligase E3 component n-recognin 4
IDBP-92122
ubiquitin protein ligase E3 component n-recognin 4
IDBP-92124
ubiquitin protein ligase E3 component n-recognin 4
IDBP-92128
ubiquitin protein ligase E3 component n-recognin 4
IDBP-373124
ubiquitin protein ligase E3 component n-recognin 4
IDBP-373126
ubiquitin protein ligase E3 component n-recognin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:19074506-19210276
Strand Reverse strand
Band p36.13
Transcripts
ENST00000375254 ENSP00000364403
ENST00000375225 ENSP00000364373
ENST00000375224 ENSP00000364372
ENST00000375218 ENSP00000364366
ENST00000425413 ENSP00000395313
ENST00000417040 ENSP00000404897
ENST00000419533
ENST00000459947
ENST00000486515
ENST00000492606
ENST00000467272
ENST00000483922
ENST00000494503
ENST00000466969
ENST00000475973
ENST00000465036
ENST00000497018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016032 viral process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066036
View Gene Order
ENSBTAG00000015240
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148078 Hs.678940
RefSeq NM_020765
HUGO
OMIM
CCDS CCDS189
HPRD 10184
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca