InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBR4

Summary

InnateDB Protein

IDBP-92128.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR4

Protein Name

ubiquitin protein ligase E3 component n-recognin 4

Synonyms

p600; RBAF600; ZUBR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000364366

InnateDB Gene

IDBG-92114 (UBR4)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269PubMed:16214886, ECO:0000269PubMed:23932781}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity