InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NACC2

Summary

InnateDB Protein

IDBP-92187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NACC2

Protein Name

NACC family member 2, BEN and BTB (POZ) domain containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000277554

InnateDB Gene

IDBG-92183 (NACC2)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. {ECO:0000269PubMed:22926524}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22926524}. Note=Predominantly associated with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010608	posttranscriptional regulation of gene expression
GO:0016575	histone deacetylation
GO:0034629	cellular protein complex localization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051260	protein homooligomerization
GO:1900477	negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage