InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPSM1

Summary

InnateDB Protein

IDBP-92260.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPSM1

Protein Name

G-protein signaling modulator 1

Synonyms

AGS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000291775

InnateDB Gene

IDBG-92256 (GPSM1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269PubMed:11024022, ECO:0000269PubMed:12642577}.

Subcellular Localization

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Expressed in intestinal cells. {ECO:0000269PubMed:12642577}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0030695	GTPase regulator activity

Biological Process

GO:0007399	nervous system development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0050790	regulation of catalytic activity