InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF1A1

Summary

InnateDB Protein

IDBP-92431.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1A1

Protein Name

eukaryotic translation elongation factor 1 alpha 1

Synonyms

CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1; EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1;

Species

Homo sapiens

Ensembl Protein

ENSP00000330054

InnateDB Gene

IDBG-92423 (EEF1A1)

Protein Structure

UniProt Annotation

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. {ECO:0000269PubMed:17177976}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.

Disease Associations

Tissue Specificity

Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 370 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	370 [view]
Protein-Protein	367 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006412	translation
GO:0006414	translational elongation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005853	eukaryotic translation elongation factor 1 complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P68104