Version 5.4
Homo sapiens Protein: VBP1
Summary
InnateDB Protein IDBP-92438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VBP1
Protein Name von Hippel-Lindau binding protein 1
Synonyms PFD3; PFDN3; VBP-1;
Species Homo sapiens
Ensembl Protein ENSP00000286428
InnateDB Gene IDBG-92436 (VBP1)
Protein Structure
UniProt Annotation
Function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269PubMed:9630229}.
Subcellular Localization Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016272 prefoldin complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR004127 Prefoldin alpha-like
IPR009053 Prefoldin
IPR016655 Prefoldin, subunit 3
PFAM PF02996
PRINTS
PIRSF PIRSF016396
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61758
PhosphoSite PhosphoSite-P61758
TrEMBL Q6FH24
UniProt Splice Variant
Entrez Gene 7411
UniGene Hs.634015
RefSeq NP_003363
HUGO HGNC:12662
OMIM 300133
CCDS CCDS14765
HPRD 02135
IMGT
EMBL AK313420 AL356738 BC046094 BT019604 CH471172 CR541932 U56833 U96759 Y17394
GenPept AAC23907 AAC50617 AAH46094 AAV38411 BAG36212 CAA76761 CAG46730 CAI41469 EAW72627 EAW72628 EAW72630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca