Version 5.4
Homo sapiens Protein: EGFL7
Summary
InnateDB Protein IDBP-92515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFL7
Protein Name EGF-like-domain, multiple 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360763
InnateDB Gene IDBG-92509 (EGFL7)
Protein Structure
UniProt Annotation
Function Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {ECO:0000269PubMed:23386126, ECO:0000269PubMed:23639441}.
Subcellular Localization Secreted, extracellular space {ECO:0000269PubMed:23386126}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007155 cell adhesion
GO:0045746 negative regulation of Notch signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR011489 EMI domain
IPR013111 EGF-like domain, extracellular
PFAM PF00008
PF07645
PF07546
PF07974
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHF1
PhosphoSite PhosphoSite-Q9UHF1
TrEMBL R4GMT3
UniProt Splice Variant
Entrez Gene 51162
UniGene Hs.91481
RefSeq NP_958854
HUGO HGNC:20594
OMIM 608582
CCDS CCDS7002
HPRD 16351
IMGT
EMBL AB125649 AF186111 AK091964 AL512735 AL590226 AY358901 AY358902 AY358903 BC012377 BC088371 CH471090 KC485578
GenPept AAF01429 AAH12377 AAH88371 AAQ89260 AAQ89261 AAQ89262 AGJ83826 BAD01469 BAG52452 CAC21666 CAH71721 EAW88247 EAW88248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca